pentobarbital will lower the level or outcome of apremilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration with sturdy CYP inducers brings about an important lower of systemic exposure of apremilast, which can cause loss of efficacy
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pentobarbital will reduce the level or outcome of disopyramide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.
pentobarbital will lower the extent or result of fostemsavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
Pentobarbital is produced by the Danish corporation Lundbeck. Use with the drug for executions is illegitimate underneath Danish regulation, and when this was uncovered, right after general public outcry in Danish media, Lundbeck stopped providing it to US states that impose the Demise penalty and prohibited US distributors from 戊巴比妥鈉製作 advertising it to any shoppers, for instance condition authorities, that practice or participate in executions of human beings.[17]
pentobarbital will reduce the level or impact of nimodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.
Barbiturates can induce hepatic microsomal enzymes leading to improved metabolism and reduced anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); clients stabilized on anticoagulant therapy may well call for dosage adjustments if barbiturates are included to or withdrawn from their dosage routine
Monoamine oxidase inhibitors (MAOI) may inhibit barbiturate metabolism and prolong barbiturate outcomes; observe closely
pentobarbital will lower the extent or result of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Contraindicated (1)pentobarbital will decrease the extent or effect of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or influence of alfentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.
pentobarbital will lessen the extent or influence of dutasteride by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.
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With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood concentrations of TCAs.